陈坚

高级研究员

Ph.D.

恶性脑瘤发生发展机制和治疗。

chenjian(at)cibr.ac.cn

https://chenlab.cibr.ac.cn

教育经历

2004年 – 2011年美国德克萨斯大学西南医学中心，遗传与发育，博士

1999年 – 2003年北京大学，生物科学，学士

工作经历

2019年至今北京脑科学与类脑研究所研究员

2014年 - 2019年苏州大学，功能纳米与软物质研究院，特聘教授

2012年 - 2014年傲锐东源生物科技有限公司，高级科学家，研发总监

研究概述

胶质母细胞瘤是恶性程度最高的肿瘤之一，经过几十年的研究，胶质瘤病人的治疗方案依然局限于传统的手术、放疗和化疗方案，而胶质母细胞瘤病人的生存期，也依然只有十几个月。我们之前的研究表明，胶质瘤很可能起源于具有自我更新能力的成体神经干细胞。在已经形成的胶质瘤中，存在着一部分表达干细胞标志物的肿瘤细胞，对于细胞的对化疗的抵抗和肿瘤复发至关重要。目前，我们一方面通过小鼠遗传学、原代肿瘤细胞等体系研究肿瘤发生和维持过程中的关键驱动的功能，另一方面在探索脑肿瘤和大脑独特免疫微环境之间的关系，并探索利用小分子抑制剂，CAR-T，溶瘤病毒等手段对肿瘤进行干预。

发表文章

1. Zhao.J, Chen J. (2026) A modular alliance: Probiotics and macrophages converge on glioblastoma. Cell Host Microbe, 34(2), 198-200. doi:10.1016/j.chom.2026.01.005

2. Huang Y, Deng Z, Zhou Z, Fu K, Liu F, Zhang H, Chen J#, Yang J#, Cao Y#. (2026) MerTK-triggered TGFβ1 autocrine signal regulates microglial response to neurodegeneration. Nat Commun. 17, 2312. doi: 10.1038/s41467-026-69189-3.

3. Wang X, Li J, Jiang C, Zhang C, Yuan L, Zhang T, Liu Y, Ma S, Kang P, Li D, Guan X#, Chen J#, Jia W#. (2026) Splicing factor FUS facilitates the progression of PIT1-lineage PitNETs by upregulating MDM2. Theranostics. 16(6), 3032-3049. doi: 10.7150/thno.124068.

4. Zhang J*, Jin Y*, Lin H, Deng J, Ju Y, Hu X, She J, Liang Z, Dai K, Qiu M, Sun K, Wang J, Yang F#, Chen J#, Yang E#, Li X#. (2025) Amplification of extrachromosomal MYC paralogs shapes immunosuppressive tumor microenvironment in small cell lung cancer. Clin Cancer Res. 31(21), 4529-4542. doi: 10.1158/1078-0432.Ccr-24-3399.

5. Zhao C*, Hu X*, Guan X*, Fu X*, Wang T*, Li M, Liu X, Zhao J, Wu D, Zhang F, Fu J, Li J, Zhang T, Jiang X#, Yan C#, Jia W#, Yang E#, Chen J#. (2025) Molecular landscape, subtypes, and therapeutic vulnerabilities of central nervous system solitary fibrous tumors. Nat Commun. 16, 7870. doi: 10.1038/s41467-025-63039-4.

6. Wu D*, Cao Y*, Chen H*, Du M, Wang T, Zhao J, Li M, Wu W, Zhang H, Yang E#, Yang J#, Chen J#. (2025) Common signatures of neutrophils in diverse disease conditions. Cell Discov. 11, 66. doi: 10.1038/s41a421-025-00818-9.

7. Ren F*, Yi Y*, Lu T*, Liu X*, Cui G, Huang S, Parada L#, Chen J#. (2025) Synthetic lethality through Gsk3β inhibition in glioma stem cells via the WNT-WWC1-YAP axis. Oncogene. 44(28), 2427-2439. doi: 10.1038/s41388-025-03418-9.

8. Zhao J*, Wu D*, Liu J*, Zhang Y*, Li C, Zhao W, Cao P, Wu S, Li M, Li W, Liu Y, Huang Y, Cao Y, Sun Y, Yang E, Ji N#, Yang J#, Chen J#. (2024) Disease-specific suppressive granulocytes participate in glioma progression. Cell Rep. 43(12). doi: 10.1016/j.celrep.2024.115014.

9. Wu M*, Wang T*, Ji N*, Lu T*, Yuan R*, Wu L*, Zhang J, Li M, Cao P, Zhao J, Li G, Li J, Li Y, Tang Y, Gao Z, Wang X, Cheng W, Ge M, Cui G, Li R, Wu A, You Y#, Zhang W#, Wang Q#, Chen J#. (2024) Multi-omics and pharmacological characterization of patient-derived glioma cell lines. Nat Commun. 15(1), 6740. doi: 10.1038/s41467-024-51214-y.

10. Xu Q, Cao Y, Kong F, Liu J, Chen X, Zhao Y, Lai C-H, Zhou X, Hu H, Fu W, Chen J, Yang J#. (2024) Multiple cancer cell types release LIF and Gal3 to hijack neural signals. Cell Res. 34(5), 345-354. doi: 10.1038/s41422-024-00946-z.

11. Yan C, Meng Y, Yang J, Chen J#, Jiang W#. (2023) Translational landscape in human early neural fate determination. Development. 150(6), dev201177. doi: 10.1242/dev.201177.

12. Wu M*, Wu L*, Wu W*, Zhu M*, Li J*, Wang Z, Li J, Ding R, Liang Y, Li L, Zhang T, Huang B, Cai Y, Li K, Li L, Zhang R, Hu B, Lin F, Wang X, Zheng S, Chen J, You Y, Jiang T#, Zhang J#, Chen H#, Wang Q#. (2023) Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow–Derived Macrophages. Cancer Res. 83(5), 771-785. doi: 10.1158/0008-5472.Can-22-1570.

13. Wu D*, Chen Q*, Chen J#. (2022) Case Report: Malignant Brain Tumors in Siblings With MSH6 Mutations. Front Oncol. 12(0), 920305. doi: 10.3389/fonc.2022.920305.

14. Wei J*, Wu D*, Zhao S, Shao Y, Xia Y, Ni D, Qiu X, Zhang J, Chen J#, Meng F#, Zhong Z#. (2022) Immunotherapy of Malignant Glioma by Noninvasive Administration of TLR9 Agonist CpG Nano-Immunoadjuvant. Adv Sci. 9(13), 2103689. doi: 10.1002/advs.202103689.

15. Chang J, Guo C, Li J, Liang Z, Wang Y, Yu A, Liu R, Guo Y, Chen J#, Huang S#. (2022) EN1 Regulates Cell Growth and Proliferation in Human Glioma Cells via Hedgehog Signaling. Int J Mol Sci. 23(3), 1123. doi: 10.3390/ijms23031123.

16. Ding S*, Lan X*, Meng Y, Yan C, Li M, Li X#, Chen J#, Jiang W#. (2021) CHD8 safeguards early neuroectoderm differentiation in human ESCs and protects from apoptosis during neurogenesis. Cell Death Dis. 12(11), 981. doi: 10.1038/s41419-021-04292-5.

17. Sanchez-Ortiz E, Cho W, Nazarenko I, Mo W, Chen J#, Parada L#. (2014) NF1 regulation of RAS/ERK signaling is required for appropriate granule neuron progenitor expansion and migration in cerebellar development. Genes Dev. 28(21), 2407-2420. doi: 10.1101/gad.246603.114.

18. Chen J, Li Y, Yu T, McKay R, Burns D, Kernie S, Parada L#. (2012) A restricted cell population propagates glioblastoma growth after chemotherapy. Nature. 488(7412), 522-526. doi: 10.1038/nature11287.

19. Chen J, McKay R, Parada L#. (2012) Malignant glioma: Lessons from genomics, mouse models, and stem cells. Cell. 149(1), 36-47. doi: 10.1016/j.cell.2012.03.009.

20. Alcantara Llaguno S*, Chen J*, Kwon C*, Jackson E, Li Y, Burns D, Alvarez-Buylla A, Parada L#. (2009) Malignant Astrocytomas Originate from Neural Stem/Progenitor Cells in a Somatic Tumor Suppressor Mouse Model. Cancer Cell. 15(1), 45-56. doi: 10.1016/j.ccr.2008.12.006.

21. Wang P*, Chen J*, Zheng A*, Nie Y, Shi X, Wang W, Wang G, Luo M, Liu H, Tan L, Song X, Wang Z, Yin X, Qu X, Wang X, Qing T, Ding M#, Deng H#. (2004) Expression cloning of functional receptor used by SARS coronavirus. Biochem Biophys Res Commun. 315(2), 439-444. doi: 10.1016/j.bbrc.2004.01.076.